Lab-grown cochlear organoids enable screening for hair cell–inducing drugs

0

Confocal microscopic image of a mouse cochlear organoid displaying hair cells (green) and their ciliary structures (red). Credit: Qing Liu, Nanjing University, China

New research published in Stem Cell Reports found that organoid culture-based models for cochlear hair cell formation can be used to identify drugs that promote hair cell regeneration in a high throughput drug library screen.

Hair cells in the ear mediate the perception of sound. Consequently, when hair cells are destroyed or lost through exposure to loud sounds, certain chemicals, disease, or aging, partial or complete hearing loss is the consequence. According to WHO estimates, one in every 10 people worldwide will have disabling hearing loss by 2050.

Lost hair cells in mammals cannot be repaired or replaced, but intriguingly hair cells in other species like fish and birds have the potential to regenerate. The reasons for those differences are not fully understood, but it means that hair cell regeneration in humans may be possible under the right conditions.

To identify those conditions, Guoqiang Wan and colleagues from Nanjing University, China, generated cultures of inner ear-like structures, so-called cochlear organoids, from immature cochlear tissue of neonatal mice. Over time, these cochlear organoids multiplied and grew hair cells in the lab. The study, recently published in Stem Cell Reports, used these cochlear organoids to screen a collection of over one thousand FDA-approved drugs for substances stimulating hair cell formation. One of the most potent substances, an anti-cancer drug called Regorafenib, promoted hair cell formation in the lab-grown cochlear organoids. Notably, this compound also promoted hair cell formation in mouse cochlear tissues. Remarkably, hair cells were even regenerated in mouse cochlear tissues after having been destroyed by chemical exposure.

This work sets the stage for high throughput screening approaches to identity stimulators of hair cell regeneration in mammals as a potential treatment for hearing loss. Before this can be applied in patients, additional research is needed to address safety and to determine if the identified drugs can induce hair cells in the human cochleas.


Scientists explore the latent regenerative potential of the inner ear


More information:
High throughput screening on cochlear organoids identifies VEGFR-MEK-TGFB1 signaling promoting hair cell reprogramming, Stem Cell Reports (2021). DOI: 10.1016/j.stemcr.2021.08.010 , www.cell.com/stem-cell-reports … 2213-6711(21)00428-8

Provided by
International Society for Stem Cell Research

Citation:
Lab-grown cochlear organoids enable screening for hair cell–inducing drugs (2021, September 14)
retrieved 14 September 2021
from https://phys.org/news/2021-09-lab-grown-cochlear-organoids-enable-screening.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

FOLLOW US ON GOOGLE NEWS

 

Read original article here

Denial of responsibility! Gamers Greade is an automatic aggregator of the all world’s media. In each content, the hyperlink to the primary source is specified. All trademarks belong to their rightful owners, all materials to their authors. If you are the owner of the content and do not want us to publish your materials, please contact us by email – [email protected]. The content will be deleted within 24 hours.

Comments
Loading...